Title : Retinoic acid increases hypoxia-inducible factor-1α through intracrine prostaglandin E(2) signaling in human renal proximal tubular cells HK-2.

Pub. Date : 2012 Apr

PMID : 22306363






1 Functional Relationships(s)
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1 Here we investigated the role of COXs (cyclooxygenases) in these effects and we found that, i) ATRA increased the expression of COX-1 and COX-2 mRNA and protein and the intracellular levels (but not the extracellular ones) of PGE(2). Tretinoin mitochondrially encoded cytochrome c oxidase II Homo sapiens