Title : Leonurine attenuates lipopolysaccharide-induced inflammatory responses in human endothelial cells: involvement of reactive oxygen species and NF-κB pathways.

Pub. Date : 2012 Apr 5

PMID : 22305882






3 Functional Relationships(s)
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1 We found that leonurine pretreatment concentration-dependently attenuated LPS-induced mRNA expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), E-selectin, and monocyte chemoattractant protein-1. leonurine vascular cell adhesion molecule 1 Homo sapiens
2 We found that leonurine pretreatment concentration-dependently attenuated LPS-induced mRNA expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), E-selectin, and monocyte chemoattractant protein-1. leonurine vascular cell adhesion molecule 1 Homo sapiens
3 Meanwhile, LPS-mediated expression/release of ICAM-1, VCAM-1, and cyclooxygenase-2, and tumor necrosis factor-alpha was also reduced by leonurine. leonurine vascular cell adhesion molecule 1 Homo sapiens