Title : Impact of tautomery of 3-(4H-1,2,4-triazol-3-ylthio)-N-phenylpropanamide on the COX-1 inhibitory mechanism.

Pub. Date : 2013 Jun

PMID : 22304495






1 Functional Relationships(s)
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1 It was also supervised that the compound 3-(4H-1,2,4-triazol-3-ylthio)-N-phenylpropanamide (6a) docked near the gate of COX-1 active site and might block the conversion of arachidonic acid to prostaglandin (PG) H2 in the active site of COXs. Arachidonic Acid mitochondrially encoded cytochrome c oxidase I Homo sapiens