Title : Mitochondria-targeted superoxide dismutase (SOD2) regulates radiation resistance and radiation stress response in HeLa cells.

Pub. Date : 2012

PMID : 22302046






2 Functional Relationships(s)
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1 Furthermore, flow cytometry with a fluorescent probe (2",7"-dichlorofluorescein) revealed that the cellular levels of ROS increased in HeLa S3 cells during post-irradiation incubation, but the increase was markedly attenuated in HeLa S3/SOD2 cells. Reactive Oxygen Species superoxide dismutase 2 Homo sapiens
2 These results indicate that SOD2 protects HeLa cells against cellular effects of gamma-rays through suppressing oxidative stress in irradiated cells caused by ROS generated in the mitochondria and through regulating the expression of genes which play a critical role in protection against ionizing radiation. Reactive Oxygen Species superoxide dismutase 2 Homo sapiens