Title : SirT1 confers hypoxia-induced radioresistance via the modulation of c-Myc stabilization on hepatoma cells.

Pub. Date : 2012

PMID : 22302044






2 Functional Relationships(s)
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1 Nevertheless, pretreatment of cells with 10058-F4, a specific inhibitor of c-Myc, almost eliminated the nicotinamide-induced radiosensitive effect. Niacinamide MYC proto-oncogene, bHLH transcription factor Homo sapiens
2 In contrast, nicotinamide attenuated c-Myc protein degradation induced by radiation under hypoxia through inhibition of SirT1 deacetylase activity. Niacinamide MYC proto-oncogene, bHLH transcription factor Homo sapiens