Pub. Date : 2012
PMID : 22302044
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | It was found that the administration with resveratrol, a putative SirT1 activator, enhanced the resistance of HepG2 cells against radiation-induced DNA damage of MN formation under hypoxia condition; while nicotinamide, a well-known SirT1 inhibitor, sensitized this radiation damage. | Niacinamide | sirtuin 1 | Homo sapiens |
| 2 | It was found that the administration with resveratrol, a putative SirT1 activator, enhanced the resistance of HepG2 cells against radiation-induced DNA damage of MN formation under hypoxia condition; while nicotinamide, a well-known SirT1 inhibitor, sensitized this radiation damage. | Niacinamide | sirtuin 1 | Homo sapiens |
| 3 | In contrast, nicotinamide attenuated c-Myc protein degradation induced by radiation under hypoxia through inhibition of SirT1 deacetylase activity. | Niacinamide | sirtuin 1 | Homo sapiens |