Pub. Date : 2012 May
PMID : 22294037
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nocodazole increases the ERK activity to enhance MKP-1expression which inhibits p38 activation induced by TNF-alpha. | Nocodazole | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | Nocodazole also weakly activated JNK, but significantly activated ERK. | Nocodazole | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | The inhibition by nocodazole of TNF-alpha-induced p38 activation was abolished by ERK-specific inhibitor U0126. | Nocodazole | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | Further exploration revealed that nocodazole significantly enhanced MKP-1 expression via the ERK activity. | Nocodazole | mitogen-activated protein kinase 1 | Homo sapiens |
| 5 | Thus, nocodazole increases the ERK activity to enhance MKP-1 expression which inhibits p38 activation induced by TNF-alpha. | Nocodazole | mitogen-activated protein kinase 1 | Homo sapiens |