Pub. Date : 2012 Apr 1
PMID : 22287576
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Endothelial overexpression of Nox2 in ApoE(-/-) mice did not alter blood pressure, but significantly increased vascular superoxide production compared with ApoE(-/-) littermates, measured using both lucigenin chemiluminescence and 2-hydroxyethidium production (ApoE(-/-), 19.9 +- 6.3 vs. Nox2-Tg ApoE(-/-), 47.0 +- 7.0 nmol 2-hydroxyethidium/aorta, P< 0.05). | Superoxides | apolipoprotein E | Mus musculus |
| 2 | CONCLUSION: Endothelial-targeted Nox2 overexpression in ApoE(-/-) mice is sufficient to increase vascular superoxide production and increase macrophage recruitment possible via activation of endothelial cells. | Superoxides | apolipoprotein E | Mus musculus |