Title : Vinca alkaloids cause aberrant ROS-mediated JNK activation, Mcl-1 downregulation, DNA damage, mitochondrial dysfunction, and apoptosis in lung adenocarcinoma cells.

Pub. Date : 2012 May 1

PMID : 22285910






2 Functional Relationships(s)
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1 Vinca alkaloids cause aberrant ROS-mediated JNK activation, Mcl-1 downregulation, DNA damage, mitochondrial dysfunction, and apoptosis in lung adenocarcinoma cells. Vinca Alkaloids mitogen-activated protein kinase 8 Homo sapiens
2 These results demonstrate an essential role of ROS in vinca alkaloid-induced aberrant JNK-mediated Mcl-1 downregulation and DNA damage followed by mitochondrial dysfunction-related apoptosis but not mitotic arrest. Vinca Alkaloids mitogen-activated protein kinase 8 Homo sapiens