Pub. Date : 2013 Jul 31
PMID : 22277574
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pioglitazone ameliorates systolic and diastolic cardiac dysfunction in rat model of angiotensin II-induced hypertension. | Pioglitazone | angiotensinogen | Rattus norvegicus |
| 2 | In the current study, we examined the effect of pioglitazone, an agonist of peroxisome proliferator activated receptor-gamma, on angiotensin II-induced intracardiac lipid accumulation and cardiac dysfunction. | Pioglitazone | angiotensinogen | Rattus norvegicus |
| 3 | Pioglitazone, given orally at a dose of 2.5mg/kg/d, reduced cardiac triglyceride content and suppressed lipid deposition in the heart of angiotensin II-induced hypertensive rats without affecting angiotensin II-induced upregulation of lipogenic gene expression. | Pioglitazone | angiotensinogen | Rattus norvegicus |
| 4 | Histological examination showed that pioglitazone reduced the area of cardiac fibrosis and iron deposition in the heart of angiotensin II-treated rats. | Pioglitazone | angiotensinogen | Rattus norvegicus |
| 5 | Angiotensin II increased the superoxide signals detected by dihydroethidium staining in myocardial cells with lipid deposition, and this increase was suppressed by pioglitazone. | Pioglitazone | angiotensinogen | Rattus norvegicus |
| 6 | It was found that pioglitazone improved both the systolic and diastolic cardiac performance, which was weakened by angiotensin II infusion, after transient ischemia and reperfusion. | Pioglitazone | angiotensinogen | Rattus norvegicus |
| 7 | These findings collectively suggest that pioglitazone treatment ameliorated the histological and functional cardiac damage induced by angiotensin II infusion, the mechanism of which may be related to the antioxidative action of pioglitazone. | Pioglitazone | angiotensinogen | Rattus norvegicus |
| 8 | These findings collectively suggest that pioglitazone treatment ameliorated the histological and functional cardiac damage induced by angiotensin II infusion, the mechanism of which may be related to the antioxidative action of pioglitazone. | Pioglitazone | angiotensinogen | Rattus norvegicus |