Pub. Date : 2012 May
PMID : 22270542
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Urotensin II (UII) and transforming growth factor (TGF)-beta are potent mitogens for ASMCs proliferation. | asmcs | transforming growth factor, beta 1 | Rattus norvegicus |
| 2 | The study was aimed to determine whether UII-upregulated TGF-beta-mediated ASMCs proliferation and extracellular signal-regulated kinase (ERK) was required for such an effect. | asmcs | transforming growth factor, beta 1 | Rattus norvegicus |
| 3 | In vitro experiments were conducted to determine the direct effect of UII on TGF-beta1 expression by ASMCs. | asmcs | transforming growth factor, beta 1 | Rattus norvegicus |
| 4 | In vitro study on ASMCs further revealed that UII may render its effect on ASMCs cells through the upregulation of TGF-beta1. | asmcs | transforming growth factor, beta 1 | Rattus norvegicus |
| 5 | The current study provides new evidence that UII is involved in the TGF-beta mediated mitogenic effect on ASMCs. | asmcs | transforming growth factor, beta 1 | Rattus norvegicus |