Title : Hydrogen peroxide enhances the expression of Giα proteins in aortic vascular smooth cells: role of growth factor receptor transactivation.

Pub. Date : 2012 Apr 15

PMID : 22268112






3 Functional Relationships(s)
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1 In addition, H(2)O(2) also increased the phosphorylation of EGF-R, PDGF-R, ERK1/2, and AKT, which was attenuated by the respective inhibitors, whereas the inhibitors of EGF-R and PDGE-R also inhibited the enhanced phosphorylation of ERK1/2 and AKT. Hydrogen Peroxide mitogen activated protein kinase 3 Rattus norvegicus
2 In addition, H(2)O(2) also increased the phosphorylation of EGF-R, PDGF-R, ERK1/2, and AKT, which was attenuated by the respective inhibitors, whereas the inhibitors of EGF-R and PDGE-R also inhibited the enhanced phosphorylation of ERK1/2 and AKT. Hydrogen Peroxide mitogen activated protein kinase 3 Rattus norvegicus
3 These results suggest that H(2)O(2) increases the expression of G(i)alpha proteins in VSMC through the transactivation of EGF-R/PDGF-R and ERK1/2 and phosphatidylinositol-3 kinase signaling pathways. Hydrogen Peroxide mitogen activated protein kinase 3 Rattus norvegicus