Pub. Date : 2012 Mar 8
PMID : 22262768
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Heme-induced cell death required TNFR1 and TLR4/MyD88-dependent TNF production. | Heme | myeloid differentiation primary response gene 88 | Mus musculus |
| 2 | Addition of TNF to Tlr4(-/-) or to Myd88(-/-) macrophages restored heme-induced cell death. | Heme | myeloid differentiation primary response gene 88 | Mus musculus |
| 3 | Taken together, these results revealed that heme induces macrophage necrosis through 2 synergistic mechanisms: TLR4/Myd88-dependent expression of TNF and TLR4-independent generation of ROS. | Heme | myeloid differentiation primary response gene 88 | Mus musculus |