Title : Modeling of molecular interaction between apoptin, BCR-Abl and CrkL--an alternative approach to conventional rational drug design.

Pub. Date : 2012

PMID : 22253690






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Apoptin attributes such as SH2-like sequence similarity with CrkL SH2 domain, unique SH3 domain binding sequence, presence of proline-rich segments, and its nuclear affinity render the molecule capable of interaction with Bcr-Abl. Proline ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens