Title : Multifunctional QD-based co-delivery of siRNA and doxorubicin to HeLa cells for reversal of multidrug resistance and real-time tracking.

Pub. Date : 2012 Mar

PMID : 22243797






3 Functional Relationships(s)
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1 In this study, two CdSe/ZnSe QDs modified with beta-CD coupled to L-Arg or L-His were used to simultaneously deliver doxorubicin (Dox) and siRNA targeting the MDR1 gene to reverse the multidrug resistance of HeLa cells. betadex ATP binding cassette subfamily B member 1 Homo sapiens
2 In this co-delivery system, Dox was firstly encapsulated into the hydrophobic cavities of beta-CD, resulting in bypass of P-glycoprotein (P-gp)-mediated drug efflux. betadex ATP binding cassette subfamily B member 1 Homo sapiens
3 In this co-delivery system, Dox was firstly encapsulated into the hydrophobic cavities of beta-CD, resulting in bypass of P-glycoprotein (P-gp)-mediated drug efflux. betadex ATP binding cassette subfamily B member 1 Homo sapiens