Pub. Date : 2012 Mar
PMID : 22232287
13 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ENT1, a ribavirin transporter, plays a pivotal role in antiviral efficacy of ribavirin in a hepatitis C virus replication cell system. | Ribavirin | solute carrier family 29 member 1 (Augustine blood group) | Homo sapiens |
| 2 | However, because the role of this transporter in the antiviral mechanism of the drug remains unclear, the present study aimed to elucidate the role of ENT1 in ribavirin antiviral action. | Ribavirin | solute carrier family 29 member 1 (Augustine blood group) | Homo sapiens |
| 3 | Nitrobenzylmercaptopurine riboside (NBMPR) and micro-RNA targeted to ENT1 mRNA (miR-ENT1) were used to reduce the ribavirin uptake level in OR6 cells. | Ribavirin | solute carrier family 29 member 1 (Augustine blood group) | Homo sapiens |
| 4 | Nitrobenzylmercaptopurine riboside (NBMPR) and micro-RNA targeted to ENT1 mRNA (miR-ENT1) were used to reduce the ribavirin uptake level in OR6 cells. | Ribavirin | solute carrier family 29 member 1 (Augustine blood group) | Homo sapiens |
| 5 | It was found that the primary ribavirin transporter in OR6 cells was ENT1 and that inhibition of ENT1-mediated ribavirin uptake by NBMPR significantly attenuated the antiviral activity of the drug as well as its accumulation in OR6 cells. | Ribavirin | solute carrier family 29 member 1 (Augustine blood group) | Homo sapiens |
| 6 | It was found that the primary ribavirin transporter in OR6 cells was ENT1 and that inhibition of ENT1-mediated ribavirin uptake by NBMPR significantly attenuated the antiviral activity of the drug as well as its accumulation in OR6 cells. | Ribavirin | solute carrier family 29 member 1 (Augustine blood group) | Homo sapiens |
| 7 | The results also showed that even a small reduction in the ENT1-mediated ribavirin uptake, achieved in this case using miR-ENT1, caused a significant decrease in its antiviral activity, thus indicating that the ENT1-mediated ribavirin uptake level determined its antiviral activity level in OR6 cells. | Ribavirin | solute carrier family 29 member 1 (Augustine blood group) | Homo sapiens |
| 8 | The results also showed that even a small reduction in the ENT1-mediated ribavirin uptake, achieved in this case using miR-ENT1, caused a significant decrease in its antiviral activity, thus indicating that the ENT1-mediated ribavirin uptake level determined its antiviral activity level in OR6 cells. | Ribavirin | solute carrier family 29 member 1 (Augustine blood group) | Homo sapiens |
| 9 | The results also showed that even a small reduction in the ENT1-mediated ribavirin uptake, achieved in this case using miR-ENT1, caused a significant decrease in its antiviral activity, thus indicating that the ENT1-mediated ribavirin uptake level determined its antiviral activity level in OR6 cells. | Ribavirin | solute carrier family 29 member 1 (Augustine blood group) | Homo sapiens |
| 10 | The results also showed that even a small reduction in the ENT1-mediated ribavirin uptake, achieved in this case using miR-ENT1, caused a significant decrease in its antiviral activity, thus indicating that the ENT1-mediated ribavirin uptake level determined its antiviral activity level in OR6 cells. | Ribavirin | solute carrier family 29 member 1 (Augustine blood group) | Homo sapiens |
| 11 | The results also showed that even a small reduction in the ENT1-mediated ribavirin uptake, achieved in this case using miR-ENT1, caused a significant decrease in its antiviral activity, thus indicating that the ENT1-mediated ribavirin uptake level determined its antiviral activity level in OR6 cells. | Ribavirin | solute carrier family 29 member 1 (Augustine blood group) | Homo sapiens |
| 12 | The results also showed that even a small reduction in the ENT1-mediated ribavirin uptake, achieved in this case using miR-ENT1, caused a significant decrease in its antiviral activity, thus indicating that the ENT1-mediated ribavirin uptake level determined its antiviral activity level in OR6 cells. | Ribavirin | solute carrier family 29 member 1 (Augustine blood group) | Homo sapiens |
| 13 | In conclusion, our results show that by facilitating its uptake and accumulation in OR6 cells, ENT1 plays a pivotal role in the antiviral effectiveness of ribavirin and therefore provides an important insight into the efficacy of the drug in anti-HCV therapy. | Ribavirin | solute carrier family 29 member 1 (Augustine blood group) | Homo sapiens |