Title : Enzymatic transamination of D-kynurenine generates kynurenic acid in rat and human brain.

Pub. Date : 2012 Mar

PMID : 22224417






1 Functional Relationships(s)
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1 In vivo, focal application of 100 muM d-kynurenine by reverse microdialysis led to a steady rise in extracellular kynurenic acid in the rat striatum, causing a 4-fold elevation after 2 h. Attesting to functional significance, this increase was accompanied by a 36% reduction in extracellular dopamine. Kynurenic Acid latexin Homo sapiens