Pub. Date : 2012 Mar
PMID : 22223356
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | MCF-10A cells morphologically transformed by long-term exposure to AlCl(3) display strong upregulation of the p53/p21(Waf1) pathway, a key mediator of growth arrest and senescence. | Aluminum Chloride | tumor protein p53 | Homo sapiens |
| 2 | These results suggest that aluminium is not generically mutagenic, but similar to an activated oncogene, it induces proliferation stress, DSBs and senescence in normal mammary epithelial cells; and that long-term exposure to AlCl(3) generates and selects for cells able to bypass p53/p21(Waf1) -mediated cellular senescence. | Aluminum Chloride | tumor protein p53 | Homo sapiens |