Title : Differential induction of stearoyl-CoA desaturase 1 and 2 genes by fibrates in the liver of rats.

Pub. Date : 2012

PMID : 22223347






4 Functional Relationships(s)
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1 The administration of fibrates (fenofibrate, bezafibrate and clofibric acid) to rats induced stearoyl-CoA desaturase (SCD) in the liver, and increased relative expression of mRNAs encoding SCD1 and SCD2 in dose- and time-dependent manners. Clofibric Acid stearoyl-CoA desaturase Rattus norvegicus
2 The administration of fibrates (fenofibrate, bezafibrate and clofibric acid) to rats induced stearoyl-CoA desaturase (SCD) in the liver, and increased relative expression of mRNAs encoding SCD1 and SCD2 in dose- and time-dependent manners. Clofibric Acid stearoyl-CoA desaturase Rattus norvegicus
3 The administration of fibrates (fenofibrate, bezafibrate and clofibric acid) to rats induced stearoyl-CoA desaturase (SCD) in the liver, and increased relative expression of mRNAs encoding SCD1 and SCD2 in dose- and time-dependent manners. Clofibric Acid stearoyl-CoA desaturase Rattus norvegicus
4 The magnitudes of the increases in SCD2 mRNA level caused by fenofibrate and clofibric acid were much higher than those of SCD1 at relatively higher doses of the fibrates, and a relatively long time (7 or 14 d) was required for significant induction of SCD2 mRNA expression compared with that of SCD1. Clofibric Acid stearoyl-CoA desaturase Rattus norvegicus