Title : PrPC displays an essential protective role from oxidative stress in an astrocyte cell line derived from PrPC knockout mice.

Pub. Date : 2012 Feb 3

PMID : 22222374






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 In cultured PrP(C)-knockout astrocytes from mice, the absence of PrP(C) caused an increase in intracellular ROS (reactive oxygen species) generation during the first 3h of H(2)O(2) treatment. Reactive Oxygen Species prion protein Mus musculus
2 In cultured PrP(C)-knockout astrocytes from mice, the absence of PrP(C) caused an increase in intracellular ROS (reactive oxygen species) generation during the first 3h of H(2)O(2) treatment. Reactive Oxygen Species prion protein Mus musculus
3 This rapid increase in ROS disrupted the cell cycle in the PrP(C)-knockout astrocytes, which increased the population of cells in the sub-G1 phase when compared with cultured wild-type astrocytes. Reactive Oxygen Species prion protein Mus musculus