Title : Augmentative effect of spinosin on pentobarbital-induced loss of righting reflex in mice associated with presynaptic 5-HT1A receptor.

Pub. Date : 2012 Feb

PMID : 22221104






4 Functional Relationships(s)
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1 KEY FINDINGS: The results demonstrated that the 5-HT(1A) agonist 8-OH-DPAT (s.c.) induced reductions in duration of LORR at 0.1, 0.5 and 1.0 mg/kg (P < 0.01), and prolongation of LORR latency at 0.5 and 1.0 mg/kg (s.c., P < 0.01) in pentobarbital (45 mg/kg, i.p. 8-Hydroxy-2-(di-n-propylamino)tetralin 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus
2 This effect of 8-OH-DPAT was antagonized either by 5-HT(1A) antagonist p-MPPI (5 mg/kg, i.p.) 8-Hydroxy-2-(di-n-propylamino)tetralin 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus
3 On the other hand, spinosin inhibited 8-OH-DPAT-induced hypothermia, which has been generally attributed to the activation of somatodendritic 5-HT(1A) autoreceptors in mice. 8-Hydroxy-2-(di-n-propylamino)tetralin 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus
4 CONCLUSIONS: Based on our previous results and the present data, it should be presumed that presynaptic 5-HT(1A) autoreceptor mechanisms may be involved in the inhibitory effect of spinosin on 8-OH-DPAT-induced hypothermia and also in the potentiating effect of spinosin on pentobarbital-induced LORR in mice. 8-Hydroxy-2-(di-n-propylamino)tetralin 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus