Pub. Date : 2012 Feb
PMID : 22221104
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | KEY FINDINGS: The results demonstrated that the 5-HT(1A) agonist 8-OH-DPAT (s.c.) induced reductions in duration of LORR at 0.1, 0.5 and 1.0 mg/kg (P < 0.01), and prolongation of LORR latency at 0.5 and 1.0 mg/kg (s.c., P < 0.01) in pentobarbital (45 mg/kg, i.p. | 8-Hydroxy-2-(di-n-propylamino)tetralin | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |
| 2 | This effect of 8-OH-DPAT was antagonized either by 5-HT(1A) antagonist p-MPPI (5 mg/kg, i.p.) | 8-Hydroxy-2-(di-n-propylamino)tetralin | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |
| 3 | On the other hand, spinosin inhibited 8-OH-DPAT-induced hypothermia, which has been generally attributed to the activation of somatodendritic 5-HT(1A) autoreceptors in mice. | 8-Hydroxy-2-(di-n-propylamino)tetralin | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |
| 4 | CONCLUSIONS: Based on our previous results and the present data, it should be presumed that presynaptic 5-HT(1A) autoreceptor mechanisms may be involved in the inhibitory effect of spinosin on 8-OH-DPAT-induced hypothermia and also in the potentiating effect of spinosin on pentobarbital-induced LORR in mice. | 8-Hydroxy-2-(di-n-propylamino)tetralin | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |