Title : Inhibition of phosphoenolpyruvate carboxykinase from Trypanosoma (Schizotrypanum) cruzi epimastigotes by 3-mercaptopicolinic acid: in vitro and in vivo studies.

Pub. Date : 1990 Oct

PMID : 2221921






1 Functional Relationships(s)
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1 On the other hand, 200 microM 3MP blocked completely the epimastigotes" catabolism of L-[U-14C]proline through the Kreb"s cycle via PEP-carboxykinase, as indicated by the disappearance of 14C label present in alanine, pyruvate, citrate, and isocitrate after 1 h of incubation in the presence of the labeled amino acid, while the amount of radioactivity present in alpha-ketoglutarate and malate doubled. isocitric acid phosphoenolpyruvate carboxykinase 1 Homo sapiens