Title : Tonic postganglionic sympathetic inhibition induced by afferent renal nerves?

Pub. Date : 2012 Feb

PMID : 22215714






1 Functional Relationships(s)
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1 Other than efferent sympathetic innervation, the kidney has peptidergic afferent fibers expressing TRPV1 receptors and releasing substance P. We tested the hypothesis that stimulation of afferent renal nerve activity with the TRPV1 agonist capsaicin inhibits efferent renal sympathetic nerve activity tonically by a neurokinin 1 receptor-dependant mechanism. Capsaicin tachykinin receptor 1 Rattus norvegicus