Title : Anti-hyperalgesic effects of anti-serotonergic compounds on serotonin- and capsaicin-evoked thermal hyperalgesia in the rat.

Pub. Date : 2012 Feb 17

PMID : 22209919






1 Functional Relationships(s)
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1 We previously reported in vitro that 5HT increases calcium accumulation in the capsaicin-sensitive population of sensory neurons with a corresponding increase in proinflammatory neuropeptide release, and both are antagonized by pretreatment with 5HT(2A) and 5HT(3) antagonists, as well as the anti-migraine drug sumatriptan. Capsaicin 5-hydroxytryptamine receptor 2A Rattus norvegicus