Title : NAD+ metabolism and NAD(+)-dependent enzymes: promising therapeutic targets for neurological diseases.

Pub. Date : 2012 Feb

PMID : 22204321






1 Functional Relationships(s)
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1 For examples, the key NAD(+)-dependent enzymes SIRT1 and SIRT2 have been indicated to strongly affect the pathological changes of PD and AD; PARP-1 inhibition can profoundly reduce the brain injury in the animal models of multiple neurological diseases; and administration of either NAD(+) or nicotinamide can also decrease ischemic brain damage. Niacinamide sirtuin 1 Homo sapiens