Title : The impact of P-glycoprotein mediated efflux on absorption of 11 sedating and less-sedating antihistamines using Caco-2 monolayers.

Pub. Date : 2012 Jun

PMID : 22188412






1 Functional Relationships(s)
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1 Altering functional P-gp in the gut is likely to influence absorption of some sedating antihistamines such as dimenhydrinate and hydroxyzine and most less-sedating antihistamines except loratadine. Hydroxyzine phosphoglycolate phosphatase Homo sapiens