Title : Angiotensin II signalling and calcineurin in cardiac fibroblasts: differential effects of calcineurin inhibitors FK506 and cyclosporine A.

Pub. Date : 2012 Feb

PMID : 22184128






2 Functional Relationships(s)
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1 We investigated effects of two calcineurin inhibitors, cyclosporine A (CsA) and tacrolimus (FK506) (10-10-10-6 mol/L, 20 mins) on activation of MAP kinases and on growth, pro-fibrotic and pro-inflammatory responses in Ang II-stimulated rat cardiac fibroblasts. Tacrolimus angiotensinogen Rattus norvegicus
2 FK506, but not CsA, attenuated Ang II-stimulated MAP kinase activation. Tacrolimus angiotensinogen Rattus norvegicus