Title : Unrestrained mammalian target of rapamycin complexes 1 and 2 increase expression of phosphatase and tensin homolog deleted on chromosome 10 to regulate phosphorylation of Akt kinase.

Pub. Date : 2012 Feb 3

PMID : 22184110






1 Functional Relationships(s)
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1 Moreover, inhibition of deregulated TORC1 in TSC2-null mouse embryonic fibroblasts or in 293 cells by down-regulation of raptor decreased the levels of the transcription factor Hif1alpha and blocked PTEN expression, resulting in enhanced phosphorylation of Akt at Thr-308 and Ser-473. Threonine TSC complex subunit 2 Mus musculus