Title : The SH2-domain of SHIP1 interacts with the SHIP1 C-terminus: impact on SHIP1/Ig-α interaction.

Pub. Date : 2012 Feb

PMID : 22182704






2 Functional Relationships(s)
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1 Interestingly, whereas the SHIP1 SH2-domain can be pulled-down with phospho-peptides corresponding to the immunoreceptor tyrosine-based activation motif (ITAM) of Ig-alpha from detergent lysates, no interaction between full-length SHIP1 and the phosphorylated Ig-alpha ITAM can be observed. Tyrosine inositol polyphosphate-5-phosphatase D Homo sapiens
2 Interestingly, whereas the SHIP1 SH2-domain can be pulled-down with phospho-peptides corresponding to the immunoreceptor tyrosine-based activation motif (ITAM) of Ig-alpha from detergent lysates, no interaction between full-length SHIP1 and the phosphorylated Ig-alpha ITAM can be observed. Tyrosine inositol polyphosphate-5-phosphatase D Homo sapiens