Pub. Date : 2011
PMID : 22174924
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | METHODS: Primary culture epithelial cells pretreated with TGF-beta1 were incubated with rosiglitazone. | Rosiglitazone | transforming growth factor beta 1 | Homo sapiens |
| 2 | RESULTS: TGF-beta1-stimulated collagen type I and fibronectin expression of ADPKD cyst-lining epithelia were inhibited by rosiglitazone in a dosage-dependent manner. | Rosiglitazone | transforming growth factor beta 1 | Homo sapiens |
| 3 | Rosiglitazone suppressed TGF-beta1 induced Smad2 activation, while ERK1/2 and P38MAPK signals remained unaffected. | Rosiglitazone | transforming growth factor beta 1 | Homo sapiens |
| 4 | Rosiglitazone could also attenuate TGF-beta1-stimulated collagen type I and fibronectin expression in primary renal tubular epithelial cells, but had no effect on TGF-beta1-induced activation of Smad2, ERK1/2 and P38 pathways. | Rosiglitazone | transforming growth factor beta 1 | Homo sapiens |
| 5 | Rosiglitazone could suppress TGF-beta1-induced collagen type I and fibronectin expression in ADPKD cyst-lining epithelia through modulation of the Smad2 pathway. | Rosiglitazone | transforming growth factor beta 1 | Homo sapiens |