Pub. Date : 2011 Dec
PMID : 22173493
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | SP cells were restored upon the removal of TGF-beta and the reversion of the cells to an epithelial phenotype, and smad3-specific siRNA reduced SP abundance in response to TGF-beta. | sp | transforming growth factor beta 1 | Homo sapiens |
| 2 | SP cells were restored upon the removal of TGF-beta and the reversion of the cells to an epithelial phenotype, and smad3-specific siRNA reduced SP abundance in response to TGF-beta. | sp | transforming growth factor beta 1 | Homo sapiens |
| 3 | In conclusion, TGF-beta-induced EMT by smad-dependent signaling pathway promotes cancer development and anti-cancer drug resistant phenotype by augmenting the abundance of GBC-SD SP cells, and a better understanding of mechanisms involved in TGF-beta-induced EMT may provide a novel strategy for preventing cancer progression. | sp | transforming growth factor beta 1 | Homo sapiens |