Title : Secretory phospholipase A2-mediated depletion of phosphatidylglycerol in early acute respiratory distress syndrome.

Pub. Date : 2012 Jun

PMID : 22173044






5 Functional Relationships(s)
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1 RESULTS: BAL sPLA2 enzyme activity was markedly elevated in ARDS samples relative to healthy subjects when measured by ex vivo hydrolysis of both phosphatidylglycerol (PG) and phosphatidylcholine (PC). Phosphatidylglycerols phospholipase A2 group IIA Homo sapiens
2 RESULTS: BAL sPLA2 enzyme activity was markedly elevated in ARDS samples relative to healthy subjects when measured by ex vivo hydrolysis of both phosphatidylglycerol (PG) and phosphatidylcholine (PC). Phosphatidylglycerols phospholipase A2 group IIA Homo sapiens
3 Enzyme immunoassay identified increased PLA2G2A protein in the ARDS BAL fluid, which was strongly correlated with the sPLA2 enzyme activity against PG. Phosphatidylglycerols phospholipase A2 group IIA Homo sapiens
4 Enzyme immunoassay identified increased PLA2G2A protein in the ARDS BAL fluid, which was strongly correlated with the sPLA2 enzyme activity against PG. Phosphatidylglycerols phospholipase A2 group IIA Homo sapiens
5 Furthermore, the sPLA2 enzyme activity against PG and PC ex vivo correlated with the BAL recovery of in vivo PG and PC, respectively, and also correlated with the altered distribution of the large and small surfactant aggregates. Phosphatidylglycerols phospholipase A2 group IIA Homo sapiens