Title : Imaging copper metabolism imbalance in Atp7b (-/-) knockout mouse model of Wilson's disease with PET-CT and orally administered 64CuCl2.

Pub. Date : 2012 Oct

PMID : 22170165






2 Functional Relationships(s)
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1 RESULTS: PET-CT analysis demonstrated higher (64)Cu radioactivity in the liver of Atp7b (-/-) knockout mice compared with that in the control C57BL WT mice (p < 0.001), following oral administration of (64)CuCl(2) as a tracer. cupric chloride ATPase, Cu++ transporting, beta polypeptide Mus musculus
2 CONCLUSIONS: PET-CT quantitative analysis demonstrated an increased level of (64)Cu radioactivity in the liver of Atp7b (-/-) KO mice compared with that in the control C57BL WT mice, following oral administration of (64)CuCl(2) as a tracer. cupric chloride ATPase, Cu++ transporting, beta polypeptide Mus musculus