Title : Protective function of nicotinamide against ketamine-induced apoptotic neurodegeneration in the infant rat brain.

Pub. Date : 2012 May

PMID : 22160932






1 Functional Relationships(s)
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1 One single dose of 1 mg/g nicotinamide was administered to a developing rat and was found to inhibit ketamine-induced neuroapoptosis by downregulating Bax, inhibiting cytochrome c release from mitochondria into cytosol, and inhibiting the expression of activated caspase-3. Niacinamide caspase 3 Rattus norvegicus