Title : Human monocytes are severely impaired in base and DNA double-strand break repair that renders them vulnerable to oxidative stress.

Pub. Date : 2011 Dec 27

PMID : 22160723






1 Functional Relationships(s)
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1 These cells exhibited a high yield of ROS-induced DNA single- and double-strand breaks and activation of the ATR-Chk1-ATM-Chk2-p53 pathway that led to Fas and caspase-8, -3, and -7 activation, whereas macrophages and DCs derived from them were protected. Reactive Oxygen Species checkpoint kinase 2 Homo sapiens