Pub. Date : 2012 Jan 6
PMID : 22155232
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Although decreased nitric oxide (NO) production via decreased phosphorylation of endothelial NO synthase at serine 1179 (eNOS-Ser(1179)) was reported to be partly involved in JNK2-derived endothelial dysfunction, JNK2 seems likely to be indirectly involved in this signaling pathway. | Serine | nitric oxide synthase 3 | Bos taurus |
| 2 | Although decreased nitric oxide (NO) production via decreased phosphorylation of endothelial NO synthase at serine 1179 (eNOS-Ser(1179)) was reported to be partly involved in JNK2-derived endothelial dysfunction, JNK2 seems likely to be indirectly involved in this signaling pathway. | Serine | nitric oxide synthase 3 | Bos taurus |
| 3 | Here, using bovine aortic endothelial cells, we examined whether JNK2 directly phosphorylated eNOS-Ser(116), a putative substrate site for the MAPK superfamily, and this phosphorylation resulted in decreased NO release. | Serine | nitric oxide synthase 3 | Bos taurus |
| 4 | JNK inhibitor SP60012 increased NO release in a time- and dose-dependent manner, which was accompanied by increased eNOS-Ser(116) phosphorylation. | Serine | nitric oxide synthase 3 | Bos taurus |
| 5 | Purified JNK2 directly phosphorylated eNOS-Ser(116)in vitro. | Serine | nitric oxide synthase 3 | Bos taurus |
| 6 | Ectopic expression of dominant negative JNK2 repressed eNOS-Ser(116) phosphorylation and increased NO production. | Serine | nitric oxide synthase 3 | Bos taurus |
| 7 | Overall, this study indicates that JNK2 is a physiological kinase responsible for eNOS-Ser(116) phosphorylation and regulates NO production. | Serine | nitric oxide synthase 3 | Bos taurus |