Title : Nitric oxide release is not required to decrease the ulcerogenic profile of nonsteroidal anti-inflammatory drugs.

Pub. Date : 2012 Jan 26

PMID : 22148253






1 Functional Relationships(s)
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1 In this regard, NSAID ester intermediates were potent and selective COX-2 inhibitors in vitro, showed equipotent anti-inflammatory activity compared to the corresponding parent NSAID, but showed a markedly reduced gastric toxicity when administered orally. Esters mitochondrially encoded cytochrome c oxidase II Homo sapiens