Title : In vitro inhibition by ketoconazole of human testicular steroid oxidoreductases.

Pub. Date : 1990 Aug 28

PMID : 2214784






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 An oral antimycotic agent, ketoconazole has been demonstrated to be an inhibitor of cytochrome P-450-dependent monooxygenases. Ketoconazole cytochrome P450 family 4 subfamily F member 3 Homo sapiens
2 From the binding mode of ketoconazole to cytochrome P-450 and the present findings, it appears likely that the agent binds to a site which is different from that of steroids or pyridine nucleotides. Ketoconazole cytochrome P450 family 4 subfamily F member 3 Homo sapiens