Title : Binding of indolylalkylamines at 5-HT2 serotonin receptors: examination of a hydrophobic binding region.

Pub. Date : 1990 Oct

PMID : 2213830






1 Functional Relationships(s)
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1 Whereas tryptamine derivatives generally display little selectivity for the various populations of 5-HT receptors, N1-n-propyl-5-methoxy-alpha-methyltryptamine (3h) binds with significant affinity (Ki = 12 nM) and selectivity at 5-HT2 receptors relative to 5-HT1A (Ki = 7100 nM), 5-HT1B (Ki = 5000 nM), 5-HT1C (Ki = 120 nM), and 5-HT1D (Ki greater than 10,000 nM) receptors. Tritium 5-hydroxytryptamine receptor 1A Homo sapiens