Title : Identification of a key motif that determines the differential surface levels of RET and TrkB tyrosine kinase receptors and controls depolarization enhanced RET surface insertion.

Pub. Date : 2012 Jan 13

PMID : 22128160






2 Functional Relationships(s)
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1 Furthermore, pharmacological and mutagenesis assays revealed that protein kinase C (PKC) and high K(+) depolarization increase RET surface levels through phosphorylation of the Thr(675) residue in the Box1 motif. Threonine ret proto-oncogene Homo sapiens
2 Finally, we found that the phosphorylation status of the Thr(675) residue influences RET mediated response to GDNF stimulation. Threonine ret proto-oncogene Homo sapiens