Pub. Date : 2012 Jan
PMID : 22127068
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Molecular modeling study on the resistance mechanism of HCV NS3/4A serine protease mutants R155K, A156V and D168A to TMC435. | Simeprevir | KRAS proto-oncogene, GTPase | Homo sapiens |
| 2 | Herein, based on the recently determined structure of NS3/4A-TMC435 complex, atomic-level models of the key residue mutated (R155K, A156V and D168A) NS3/4A-TMC435 complexes were constructed. | Simeprevir | KRAS proto-oncogene, GTPase | Homo sapiens |
| 3 | Herein, based on the recently determined structure of NS3/4A-TMC435 complex, atomic-level models of the key residue mutated (R155K, A156V and D168A) NS3/4A-TMC435 complexes were constructed. | Simeprevir | KRAS proto-oncogene, GTPase | Homo sapiens |
| 4 | Herein, based on the recently determined structure of NS3/4A-TMC435 complex, atomic-level models of the key residue mutated (R155K, A156V and D168A) NS3/4A-TMC435 complexes were constructed. | Simeprevir | KRAS proto-oncogene, GTPase | Homo sapiens |
| 5 | Herein, based on the recently determined structure of NS3/4A-TMC435 complex, atomic-level models of the key residue mutated (R155K, A156V and D168A) NS3/4A-TMC435 complexes were constructed. | Simeprevir | KRAS proto-oncogene, GTPase | Homo sapiens |
| 6 | These findings could provide some insights into the resistance mechanism of NS3/4A protease mutants to TMC435 and would be critical for the development of novel inhibitors that are less susceptible to drug resistance. | Simeprevir | KRAS proto-oncogene, GTPase | Homo sapiens |