Title : Understanding the relative affinity and specificity of the pleckstrin homology domain of protein kinase B for inositol phosphates.

Pub. Date : 2012 Jan 14

PMID : 22121510






3 Functional Relationships(s)
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1 It is therefore of great interest to understand PKB"s mode of binding, as well as its specificity and affinity for different phosphoinositides. Phosphatidylinositols protein tyrosine kinase 2 beta Homo sapiens
2 We have used a total of 3 mus of molecular dynamics (MD) simulations to better understand the interactions of the PKB PH domain with the inositol phosphate head-groups of phosphoinositides involved in the PI3K pathway. Phosphatidylinositols protein tyrosine kinase 2 beta Homo sapiens
3 Our computational models successfully mirror PKB"s in vivo selectivity for 3-phosphorylated phosphoinositides. Phosphatidylinositols protein tyrosine kinase 2 beta Homo sapiens