Title : Inactivation of SAG E3 ubiquitin ligase blocks embryonic stem cell differentiation and sensitizes leukemia cells to retinoid acid.

Pub. Date : 2011

PMID : 22110742






1 Functional Relationships(s)
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1 Mechanistically, RA sensitization by MLN4924 was mediated via enhanced apoptosis, likely through accumulation of pro-apoptotic proteins NOXA and c-JUN, two well-known substrates of SAG-SCF E3 ligase. Tretinoin Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens