Title : Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability.

Pub. Date : 2011 Dec 6

PMID : 22106302






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Glutamine-derived alpha-ketoglutarate is reductively carboxylated by the NADPH-linked mitochondrial isocitrate dehydrogenase (IDH2) to form isocitrate, which can then be isomerized to citrate. isocitric acid isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens