Pub. Date : 2012 Mar
PMID : 22106171
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Itraconazole (ITZ) is a mixture of four cis-stereoisomers that inhibit CYP3A4 potently and coordinate CYP3A4 heme via the triazole nitrogen. | Heme | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | Itraconazole (ITZ) is a mixture of four cis-stereoisomers that inhibit CYP3A4 potently and coordinate CYP3A4 heme via the triazole nitrogen. | Heme | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | The catalytic rates of dioxolane ring scission were similar to the dissociation rates of ITZ stereoisomers from CYP3A4, suggesting that the heme iron is reduced while the triazole moiety coordinates to it and no dissociation of ITZ is necessary before catalysis. | Heme | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |