Title : Concentration-dependent dual effects of hydrogen peroxide on insulin signal transduction in H4IIEC hepatocytes.

Pub. Date : 2011

PMID : 22102892






1 Functional Relationships(s)
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1 Treatment with high concentrations of H2O2 (25-50 microM) for 3 h reduced insulin-stimulated Akt phosphorylation, and increased the phosphorylation of both JNK and its substrate c-Jun. Hydrogen Peroxide Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens