Title : NADPH oxidase 4 mediates monocyte priming and accelerated chemotaxis induced by metabolic stress.

Pub. Date : 2012 Feb

PMID : 22095986






1 Functional Relationships(s)
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1 METHODS AND RESULTS: Chronic exposure of monocytes to diabetic conditions induced by human LDL plus high D-glucose concentrations (LDL+HG) promoted NADPH Oxidase 4 (Nox4) expression, increased intracellular H(2)O(2) formation, stimulated protein S-glutathionylation, and increased chemotaxis in response to MCP-1, platelet-derived growth factor B, and RANTES. Glucose C-C motif chemokine ligand 2 Homo sapiens