Title : The expression and pharmacological characterization of nicotinic acetylcholine receptor subunits in HBE16 airway epithelial cells.

Pub. Date : 2012 Apr

PMID : 22095388






2 Functional Relationships(s)
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1 Cells pretreated with nicotine prior to lipopolysaccharide (LPS) stimulation exhibited a lower production of TNF-alpha, IL-8, and IL-6 compared to LPS-treated (only) cells. Nicotine C-X-C motif chemokine ligand 8 Homo sapiens
2 Cells that were transfected with alpha7 siRNA and subsequently incubated with nicotine and LPS, exhibited a higher expression of TNF-alpha, IL-8, and IL-6 compared with non-transfected cells or alpha1 and alpha5 siRNA-transfected cells. Nicotine C-X-C motif chemokine ligand 8 Homo sapiens