Title : Associations of ABCB1 3435C>T and IL-10-1082G>A polymorphisms with long-term sirolimus dose requirements in renal transplant patients.

Pub. Date : 2011 Dec 27

PMID : 22094953






1 Functional Relationships(s)
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1 BACKGROUNDS: Sirolimus (SRL) absorption and metabolism are affected by p-glycoprotein-mediated transport and CYP3A enzyme activity, which are further under the influences of cytokine concentrations. Sirolimus cytochrome P450 family 3 subfamily A member 4 Homo sapiens