Title : Tityus zulianus venom induces massive catecholamine release from PC12 cells and in a mouse envenomation model.

Pub. Date : 2012 Jan

PMID : 22085992






4 Functional Relationships(s)
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1 The nicotinic-acetylcholine receptor (nAChR) blocker hexamethonium induced a significant inhibition of the [(3)H]dopamine release produced by CC in PC12 cells but the TZ-elicited release of [(3)H]dopamine was 70% hexamethonium-insensitive, suggesting unidentified TZ toxins affecting other regulatory mechanisms of catecholamine secretion. Hexamethonium cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus
2 The nicotinic-acetylcholine receptor (nAChR) blocker hexamethonium induced a significant inhibition of the [(3)H]dopamine release produced by CC in PC12 cells but the TZ-elicited release of [(3)H]dopamine was 70% hexamethonium-insensitive, suggesting unidentified TZ toxins affecting other regulatory mechanisms of catecholamine secretion. Hexamethonium cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus
3 The nicotinic-acetylcholine receptor (nAChR) blocker hexamethonium induced a significant inhibition of the [(3)H]dopamine release produced by CC in PC12 cells but the TZ-elicited release of [(3)H]dopamine was 70% hexamethonium-insensitive, suggesting unidentified TZ toxins affecting other regulatory mechanisms of catecholamine secretion. Hexamethonium cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus
4 The nicotinic-acetylcholine receptor (nAChR) blocker hexamethonium induced a significant inhibition of the [(3)H]dopamine release produced by CC in PC12 cells but the TZ-elicited release of [(3)H]dopamine was 70% hexamethonium-insensitive, suggesting unidentified TZ toxins affecting other regulatory mechanisms of catecholamine secretion. Hexamethonium cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus